Science on Tap!
A new discussion series for the community led by graduate students in the School of Molecular and Cellular Biology. Hosted by the MCB Graduate Student Association and held at Riggs Beer Company.
The public is welcome to attend to lean more about what some of the graduate students and the University of Illinois are working on.
PhD student in Biochemistry
Engineering a Human Immunodeficiency Virus (HIV) protein to assist HIV treatment design
The HIV-1 gp160 protein fluctuates among a range of conformations – closed, partially open, and open – exposing different antibody target sites. The “closed” gp160 conformation is a primary target in current vaccine design efforts because it hides poor target sites while exposing conserved target sites. Deep mutational scanning was used to provide insight into gp160 acquiring open and closed conformations; we hope these findings may assist HIV-1 treatment design.